TukeyHSD adjusted P value is 0.0000000

问题

I just performed a factorial ANOVA, followed by the TukeyHSD post-test. Some of my adjusted P values from the TukeyHSD output are 0.0000000. Can these P values really be zero? Or is this a rounding situation, and my true P value might be something like 1e-17, that is rounded to 0.0000000.

Are there any options for the TukeyHSD() function in R that will give output P-values that contain exponents?

Here is a snippet of my output:

TukeyHSD(fit)

  Tukey multiple comparisons of means
    95% family-wise confidence level

Fit: aov(formula = lum ~ cells * treatment)

$`cells:treatment`
                    diff         lwr          upr     p adj
NULL:a-KR:a     -266.5833333 -337.887800 -195.2788663 0.0000000
WT:a-KR:a       -196.3333333 -267.637800 -125.0288663 0.0000000
KR:ar-KR:a        83.4166667   12.112200  154.7211337 0.0053485
NULL:ar-KR:a    -283.5000000 -354.804467 -212.1955330 0.0000000
WT:ar-KR:a      -196.7500000 -268.054467 -125.4455330 0.0000000
KR:e-KR:a       -219.0833333 -290.387800 -147.7788663 0.0000000
NULL:e-KR:a     -185.0833333 -256.387800 -113.7788663 0.0000000
WT:e-KR:a        -96.1666667 -167.471134  -24.8621996 0.0003216

回答1:

EDIT: see warning below about resolution of Tukey p-values!!

dd <- data.frame(y=c(1:10,1001:1010),f=rep(c("A","B"),each=10))
fit <- aov(y~f,data=dd)

The printed p-value is zero:

(tt <- TukeyHSD(fit))
##   Tukey multiple comparisons of means
##     95% family-wise confidence level
## 
## Fit: aov(formula = y ~ f, data = dd)
## 
## $f
##     diff      lwr      upr p adj
## B-A 1000 997.1553 1002.845     0

But looking at the (abbreviated) output of str() shows there's more information there:

str(tt)

## List of 1
##  $ f: num [1, 1:4] 1.00e+03 9.97e+02 1.00e+03 2.62e-14
##   ..- attr(*, "dimnames")=List of 2
##

You can extract the value yourself:

tt$f[,"p adj"]
## [1] 2.620126e-14

Or as noted in the comments, print(tt,digits=15) will work ...

WARNING

I decided to dig a little deeper and noticed in digging through the code of TukeyHSD.aov() that it relies on ptukey(), which in its "Examples" section warns that "the precision may not be more than about 8 digits". In particular, once the t-statistic is above about 30, the p-value maxes out (mins out?) at 2.62e-14 ...

zval <- 10^seq(1,6,length=100)
pval <- ptukey(zval,2,18,lower.
par(las=1,bty="l")
plot(zval,pval,log="xy",type="l")

The bottom line is that you can't distinguish among p-values this small at all. You may need to rethink your strategy ...

来源：https://stackoverflow.com/questions/16470404/tukeyhsd-adjusted-p-value-is-0-0000000

标签

anova