Circos plot issue with genes and patient mutation frequency

回眸只為那壹抹淺笑 提交于 2019-12-11 17:59:00

问题


I have already asked this question in the bioinformatics section but i see here there are more circos related query so i would like to post my question here again question

There are R packages which i haven't tried as the original circos was bit easier on my side to make the data format and run it but im not getting the plot as i would like to given that its generating but looks pretty dumb sort of difficult to infer .

So i have one set of file which contain gene and their chromosome location and the other set of file chromosome location of all the genes along with the patient mutation .

  • DC3_DC7_CIRCOS_CHR_DATA this is my location data
  • DC3_DC7_CORD_PLOT this contains gene mutation in patient
  • exp.conf is my configure file

This was my earlier question but now I would like to see patient sample mutation which i have tried and im getting an output but it looks really dumb Circos output

So here are my files

In my file which im trying to plot is gene having mutation in terms of patient which ranges from 1 to 53 patient at max .

NPM1 is having the highest mutation with 53 patient in the plot what i tried is to set a threshold of between > 10 and < 3 to set the color label ,which labels the number it contains.

  • How can i add the gene names to the plot ?
  • Is there a way where i can show the genes with only 1 mutation are linked together ,similarly for 2 linked together so on and so forth .

I tried with the links but couldn;t make it work.

There might be very fundamental which i m not able to make it work i think as

Any suggestion or help would be highly appreciated .

If there is any R solution using the data i have provided it would also be very helpful as well

来源:https://stackoverflow.com/questions/54092019/circos-plot-issue-with-genes-and-patient-mutation-frequency

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