I've searched for hours with no avail. I've seen it everywhere that libusb_detach_kernel_driver isn't supported on Mac OS X, but I haven't been able to find a patch or alternative for it.
libusb_claim_interface returns this: libusb: 0.863377 error [darwin_claim_interface] USBInterfaceOpen: another process has device opened for exclusive access
How can I detach the USB device from the kernel?
Many devices automatically have a driver attached to the USB device they are recognised as by OSX and you will not be able to claim the device unless you force the system to detach the device manually before you can run your code and claim the device. If for example it attached the AppleUSBCDC device to some unique usb device you plugged in you'd have to do:
sudo kextunload -b com.apple.driver.AppleUSBCDC
before running your application which tries to claim the interface.
来源：https://stackoverflow.com/questions/15102168/libusb-claim-interface-fails-on-mac-os-x-mountain-lion