Visual Studio 2010 adds a zoom setting on the bottom left of the text editor (to the left of the horizontal scroll bar) and also adopts the Ctrl+mouse scroll idiom for zooming in and out.
The former is fine, but I dislike the latter as I am occasionally still holding control when I start scrolling my source code (which results in the text size radically changing and completely throwing me off whatever I was doing).
How do I disable it?
Go to Tools->Extension manager, and search the online gallery for "wheel". Download "Disable Mouse Wheel Zoom"
Or use this direct link: Disable Mouse Wheel Zoom.
It is possible that Visual Studio 2010 will get into a state where ordinary use of the mouse wheel (ie without Ctrl pressed) results in text increasing or decreasing in size.
Use ctrl + scroll on the page to recover from this state.
I don't believe there is a way to do this the editor through the exposed options. However Noah Richards, a visual studio platform developer, wrote a Visual Studio extension that disables the mouse scroll zooming.
This is a problem throughout Windows, not just in Visual Studio. To disable Ctrl-Scroll zooming behavior throughout Windows, you can use AutoHotKey as described in this answer:
^WheelDown::return
^WheelUp::return
This just reprograms AutoHotKey to do nothing on Ctrl-Scroll.
来源：https://stackoverflow.com/questions/2861655/how-to-disable-zoom-on-ctrlscroll-in-visual-studio-2010