问题
I use many application on BizTalk 2009. I have noticed many times that, after a resource add (.dll) in a random application, all the bindings (custom pipelines) of a precise application totally reset to an early previous state.
I'm really curious of why this happens. But I also need a solution to stop that behavior or resolve automatically this problem.
回答1:
It happens because it tries to apply a cached binding after you have deployed. Sometimes it doesn't correctly update the cached binding and so a stale copy is used. As per below, clearing these cached copies out helps in the short term, but often it comes back.
From BizTalk Server: List of Errors and Warnings, Causes, and Solutions
Visual Studio uses cached binding files when deploying BizTalk applications. Removing these cached binding files will result in a ‘clean’ deployment that should resolve any binding related deployment errors. The files are stored in %APPDATA%\Microsoft\BizTalk Server\Deployment\BindingFiles. Clearing the contents of this directory should resolve any deployment issues related to cached bindings.
See also Import MSI change port pipelines
回答2:
Yes, this is frustrating and intermittent problem with BizTalk Sever 2009 and 2010. I don't think there every was a guaranteed resolution, sorry.
However, you should not experience this if you are deploying your apps as complete packages using BTDF or just .msi+Bindings.
来源：https://stackoverflow.com/questions/42762476/unexpected-bindings-reset-on-biztalk-2009