covariance structure for multilevel modelling
问题 I have a multilevel repeated measures dataset of around 300 patients each with up to 10 repeated measures predicting troponin rise. There are other variables in the dataset, but I haven't included them here. I am trying to use nlme to create a random slope, random intercept model where effects vary between patients, and effect of time is different in different patients. When I try to introduce a first-order covariance structure to allow for the correlation of measurements due to time I get