Funnily enough I just spent two weeks overhauling (read implementing from scratch) our nightly build process. Great fun (no, really). I toyed with the idea of installing Team Foundation Server, but we use Perforce for source control and I didn't think it was worth the hassle.
Our process is now a set of Powershell scripts that run on a dedicated build/test server that do the following on a scheduled task:
Wipe out the entire source tree (check that you didn't have anything checked out first!)
Bring down the entire source tree from Perforce (from the last labelled build)
Generate a change report (by syncing to HEAD and watching what comes down)
Build the App
Index the PDB files to the Perforce sources
Store the binaries and symbols in a dedicated symbol server
Run the test projects
Build the installer
Label
Send out emails to the group with status reports on all of the above
Works well.