I switched from NAnt to using Python to write build automation scripts. I am curious if whether any build frameworks worth using that are similar to Make, Ant, and NAnt, but, i
The Python wiki maintains a page on python build and deployment tools.
My Rapid Throughts: SCons is quite mature and oriented also to other languages (es C++) Waf is very simlar to ant/maven, so you will prefer it if you are used to ant/maven
Paver is very pythonic oriented, and seems a good option if you do not know how to start.
The following look good, but I haven't used them (yet):
Paver looks especially promising.
Try SCons
Or are you looking for something just to build python projects?
There is also Fabric but it's specially geared towards deployment rather than generic building.