I would send a '400 Bad Request' header back in response with information in json of what went wrong. Then catch the event with jquerys $.ajaxError() event handler and parse the error message i got in return to deliver good feedback to the end user.
You can read more about the ajaxError event handler here!
I agree with the 400 Bad Request response.
For inspiration you could have a look at how Twitter (widely used JSON service) does this: https://dev.twitter.com/overview/api/response-codes
Code
Text
Description200
OK
- Success! 304
Not Modified
- There was no new data to return. 400
Bad Request
- The request was invalid or cannot be otherwise served. An accompanying error message will explain further. Requests without authentication are considered invalid and will yield this response. 401
Unauthorized
- Missing or incorrect authentication credentials. Also returned in other circumstances (for example, all calls to API v1 endpoints return 401). 403
Forbidden
- The request is understood, but it has been refused or access is not allowed. An accompanying error message will explain why. This code is used when requests are being denied due to update limits . Other reasons for this status being returned are listed alongside the response codes in the table below. 404
Not Found
- The URI requested is invalid or the resource requested, such as a user, does not exists. Also returned when the requested format is not supported by the requested method. 406
Not Acceptable
- Returned when an invalid format is specified in the request. 410
Gone
- This resource is gone. Used to indicate that an API endpoint has been turned off. 420
Enhance Your Calm
Returned when an application is being rate limited . 422
Unprocessable Entity
- Returned when an image uploaded to POST account / update_profile_banner is unable to be processed. 429
Too Many Requests
- Returned when a request cannot be served due to the application’s rate limit having been exhausted for the resource. See Rate Limiting . 500
Internal Server Error
= Something is broken. Please post to the developer forums with additional details of your request, in case others are having similar issues. 502
Bad Gateway
- Twitter is down or being upgraded. 503
Service Unavailable
- The Twitter servers are up, but overloaded with requests. Try again later. 504
Gateway Timeout
- The Twitter servers are up, but the request couldn’t be serviced due to some failure within our stack. Try again later.