If your motivation is to find out how to write code that works faster or uses less memory the VM spec won't help too much.
The VM spec isn't designed to give you information about that, it is designed to let VM developer know, roughly, how to implement the VM.
That being said it cannot hur to read it.
The best way to find out about speed/memory issues is at a much higher level, there are any number of books that will help you faster/leaner code.
A profiler is an invaluable tool for testing your code to see what is faster/uses less memory. Profile, see what is slow/uses a lot of memory, change it, profile, see what the changes did.