We are a medium-sized academic research lab whose main outputs are new statistical methods for analyzing large datasets. We generally develop in R and MATLAB/Octave.
We
That's a tall order -- multi-platform, multi-backend (R and Ocatve), as well and cheap, fast and easy to use!
From the top of my head, look at these
Sage: they have what they call notebooks which are interactive web pages and showed a nice demo at useR! 2010; I think Octave is covered too
Shogun: which also integrates to Python, R and Octave and may have some tools for you to leverage.