This is a topic i myself have pondered for a while but I have not really come to a decision, as usual time is the main problem... ;)
And since I can´t find these links sofar in this post i add them for public interest:
Success and Failure story:
Lisping at JPL
Really impressive success story:
Lisp in use at the Orbitz corporation
Comparison and analysis of whether to use Lisp instead of Java:
Lisp as an Alternative to Java