Lisp can be used anywhere you use traditional programming. It's not that different, it's just more powerful. Writing a web app? you can do it on Lisp, writing a desktop application? you can do it on Lisp, whatever, you can probably do it on Lisp, or Python, or any other generic programming (there are a few languages that are suited for only one task).
The biggest obstacle will probably be acceptance of your boss, your peers or your customers. That's something you will have to work with them. Choosing a pragmatic solution like Clojure that can leverage the current install base of Java infrastructure, from the JVM to the libraries, might help you. Also, if you have a Java program, you may do a plug-in architecture and write Clojure plug-ins for it and end up writing half your code in Clojure.