I have experience with Qt and wxWidgets. Both are OK for simple GUI applications, but Qt looks more professional. I like that it keeps GUI definition code in separate files (like in .NET WinForms designer), and it is not mixed with our own code. Qt Creator is good IDE which may be used also for developing non-Qt C/C++ applications.
In Ubuntu, both Qt and wxWidgets are available in the repository, and can be installed by standard way, without building the source.