If what you need is to have several domains that point to the same Joomla (and to the same content) the answer is YES (see @S.Mark's answer).
If you want to use the same Joomla installation for two different websites (with different content), the answer is NO.
An alternative is to use some Joomla extension, such as:
http://extensions.joomla.org/extensions/core-enhancements/multiple-sites/5550