Let\'s say that myURL pointed to a PDF which was obtained by doing:
myURL = [[NSBundle mainBundle] URLForResource:@\"my\" withExtension:@\"PDF\"];
As far as I know it is not possible to hand a local PDF file off to MobileSafari.
But you can easily hand off a local PDF file to any locally installed application that acts as a PDF viewer. i.e., iBooks, GoodReader, etc. If this is sufficient, you should take a look at UIDocumentInteractionController. It will present a menu of apps, and let the user choose one to open the file in. Unfortunately, Safari itself does not register as a PDF viewer.
(If you did decide to present PDFs yourself, the QLPreviewController will display the file and give you the "send to other app" functionality.)
This is not currently possible.