I am trying to set an image as wallpaper through my windows 8 Metro App. I am getting this error when I try to do it \"Creating an instance of the COM component with CLSID {750
The set of COM objects which can be accessed by a windows store app is extremely limited. Looking at the MSDN documentation, it appears that CLSID_ActiveDesktop is not one of the classes that's allowed to be accessed by store apps.
As Hans mentioned in his comment, store apps aren't allowed to interfere with per-user state - actions like changing the desktop wallpaper count as changing user state.