One of my projects has stopped being able to run debug.. From one moment to another I get the response \"This site can\'t be reached\" when running the debugger in VS2017. I
The problem for me turned out to be that my web.config had a rule that was rewriting the URL to use https instead of http. After I removed the section from my web.config, I was able to debug the site.
I finally found an answer that worked for me here.
It is suggested to uncheck "Edit and Continue" in the debugger menu. I combined this with (just to be sure) deleting the vs and the bin folders and restarted Visual Studio. I am not sure what the issue was, but it is solved now at least.