I have recently started to received this message.
Unable to start debugging on the web server.
The IIS worker process for the launched URL is not currently
I got the same error message after reinstalling VS2010. In my case all application pools in the IIS where remapped to run 4.0, so VS2010 was unable to figure out which pool to attach its self to during debugging. The solution in my case, was to manually delete few pools and remapping my older pools back to .net 2.0. I finally ended up, only having 2 pools pointing towards .net 4.0 (integrated and classic) and 2 pools running .net 2.0 (integrated and classic).