In the near future, I have to update a bigger XPage application (development time more than three years) now running on a Domino Server 8.5.3 FP6
to Domin
a big advantage with Bootstrap in comparison with oneUI is that there are many sites where snippets for controls / layouts / panels are being shared.
if you stick close to the oneUI defintion you are limited in your presentation options.
also Bootstrap is targetted against multiple clients (mobil / desktop / large) which oneUI is not. so if that is a requirement I definitely recommend bootstrap above oneUI.
there is a learning curve with Bootstrap but manageable.
with Bootstrap I hardly use dojo anymore and disable it in xpages whenever possible.
there are also limitations with bootstrap, e.g. motion awareness but you can overcome them with plugins. you would probably experience the same limitations with oneUI.
once you go bootstrap, you can't get back (to oneUI).
I have little experience with other front-end frameworks so I can not advice on that.
I use oneUI at the day job. There are some very good things about it. However, I'm trying to get my company and all my personal work migrated to Bootstrap. OneUI is not really responsive. Even if that's not a big issue for you the biggest reason to avoid oneUI is the lack of documentation and materials for it. There actually is documentation for oneUI But nothing like Bootstrap - the most popular framework going as far as I know. Heck right here on StackOverFlow over 59,000 questions have been asked on Bootstrap. There's tons of resources like bootsnipp.com. In my opinion it's almost a no brainer that Bootstrap should be used over oneUI if at all possible.
Yes, I agree you are right. IBM is staying in front of the curve in supporting Bootstrap for the future. I don't believe that they are investing any more resources in OneUI at this point in time. (Good news, IMO)
On the surface, your question appears opinion based, but really you need to be concerned with the level of support/investment by the IBM XPages team.
If you haven't view it already, I would recommend the TLCC webinar given this month (Feb 2016) by Brian Gleeson and Martin Donnelly on Responsive Design using Bootstrap with XPages. The team is being extremely proactive in preparing to support Bootstrap 4 which isn't even released yet.
This is the link to the webinar which is very well done: https://youtu.be/0ylbKHyiFyY
As long as IBM won't deliver us the new "Verse" UI (which I'd refer to as OneUI Next) I'd prefer the Bootstrap UI as it is responsive. I wouldn't say that it's IBM's future UI framework as departments seem to develop indepently IMHO. The Ireland guys are proclaiming Bootstrap but the IBM Design team propagate their own styles. As always: not a straight strategy here. But when it comes to application modernization I'd prefer Bootstrap. The next iteration will include Bootstrap 4, too (the final version). Anyway, using Bootstrap instead of OneUI will deliver more straight and simplified CSS classes other than the "LotusUI" stuff in OneUI.
Just my 2 cents.