There's always SQLite, a database that's stored in a file. SQLite already has built-in concurrency, so you don't have to worry about things like file locking, and it's really fast for reads.
If, however, you are doing lots of database changes, it's best to do them all at once inside a transaction. This will only write the changes to the file once, as opposed to every time an change query is issued. This dramatically increases the speed of doing multiple changes.
When a change query is issued, whether it's inside a tranasction or not, the whole database is locked until that query finishes. This means that extremely large transactions could adversely affect the performance of other processes because they must wait for the transaction to finish before they can access the database. In practice, I haven't found this to be that noticeable, but it's always good practice to try to minimize the number of database modifying queries you issue.
