A method in dumping a GridView to an Excel file to download/open from the internet was recently broken with new Windows Updates.
My code dumps from a GridView to an
Per Raniel66's suggestion, if the excel opens as blank even after adding the site to your Trusted Sites list, you may try/suggest below work around.
Open excel workbook even though it is grayed out/blank, then click on ‘View’ tab in the excel and then click on 'full screen/maximize screen icon' as shown in screen shot below. This is what worked for me.