A couple of solutions.
You can take advantage of the fact that SQL does not COUNT NULL values:
SELECT US_LOGON_NAME as Username,
COUNT(CASE WHEN <cond> THEN I.IS_ISSUE_NO ELSE NULL END)
COUNT(CASE WHEN <other cond> THEN I.IS_ISSUE_NO ELSE NULL END)
. . .
Or you can use SUM instead of COUNT:
SELECT US_LOGON_NAME as Username,
SUM(CASE WHEN <cond> THEN 1 ELSE 0 END)
SUM(CASE WHEN <other cond> THEN 1 ELSE 0 END)
. . .
In either case, you can repeat as many times as you need to.