I\'m having some issues with the iPhone simulators after upgrading to Lion and XCode 4.1. When I launch the simulator for 4.0, 4.1 or 4.2 (which I restored from Time Machine
I ran into this as well. I fixed it by removing my /Developer dir, installing Xcode 4.1, then installing Xcode 4.2, THEN installing the latest iTunes 10.5 beta. Haven't had issues since.