I am trying to edit a word document from VB.NET using for the most part this code:
How to automate Word from Visual Basic .NET to create a new document
I had the same problem while generating word document. The issue i solved by checking the task manager, and by ending the currently running process WINWORD.EXEs and then executed my code again. The issue gone.
This appears to be what you are experiencing.
http://social.msdn.microsoft.com/Forums/en-US/netfxbcl/thread/006cbbac-101a-40ea-ae16-d59a7a2da8b1