For WPF:
private void textBox1_PreviewTextInput(object sender, TextCompositionEventArgs e)
{
if (!char.IsDigit(e.Text, e.Text.Length - 1))
e.Handled = true;
}
For Windows Forms:
private void textBox1_KeyPress(object sender, KeyPressEventArgs e)
{
if (!char.IsDigit(e.KeyChar) )
e.Handled = true;
}