Define a new coordinate system with two rectangle sides as unit vectors and transform the coordinate of the point into the new coordinate system. If both coordinates are between 0 and 1, it's inside.
In equations (assuming A,B,C,D are corners of the rectangle, P is the point, _x and _y are the x and y components):
P_x = A_x + x * (B_x - A_x) + y * (D_x - A_x)
P_y = A_y + x * (B_y - A_y) + y * (D_y - A_y)
Solve for x and y and check if they are between 0 and 1
Written as linear equation system (A,B,C,D,P are vectors of length 2):
[ | ] [x] [ ]
[B-A | D-A] * [ ] = [P-A]
[ | ] [y] [ ]
Solving is easy as it has only two dimensions and you can be sure that you are not singular.