In Python 3.3+, you can use ipaddress module:
>>> import ipaddress
>>> ipaddress.ip_address('192.0.43.10') in ipaddress.ip_network('192.0.0.0/16')
True
If your Python installation is older than 3.3, you can use this backport.
If you want to evaluate a lot of IP addresses this way, you'll probably want to calculate the netmask upfront, like
n = ipaddress.ip_network('192.0.0.0/16')
netw = int(n.network_address)
mask = int(n.netmask)
Then, for each address, calculate the binary representation with one of
a = int(ipaddress.ip_address('192.0.43.10'))
a = struct.unpack('!I', socket.inet_pton(socket.AF_INET, '192.0.43.10'))[0]
a = struct.unpack('!I', socket.inet_aton('192.0.43.10'))[0] # IPv4 only
Finally, you can simply check:
in_network = (a & mask) == netw