Some highlights:
NASA http://www.flownet.com/gat/jpl-lisp.html
Crash Bandicoot & Jak+Daxter http://www.gamasutra.com/features/20020710/white_02.htm
Interface Builder OS X (which was later rewritten in Objective-C)
Emacs
All of the above are projects of great complexity. In the case of Interface Builder and Emacs one could reasonably argue that they have not been surpassed. Of course Interface Builder has not been written in Lisp in over two decades, but I think this list also points out that a powerful language like Lisp inspires hackers to attempt projects you normally wouldn't even consider in a less expressive language.
