I\'m starting to get involved in an open source project Gramps which is exploring switching their backend from BSDDB to a relational database. Either SQLite or MySQL we have
If your project will ever have any real complexity, stay away from ORMs.
http://blogs.tedneward.com/2006/06/26/The+Vietnam+Of+Computer+Science.aspx
I really like Storm:
Storm is an object-relational mapper (ORM) for Python developed at Canonical. The project has been in development for more than a year for use in Canonical projects such as Launchpad, and has recently been released as an open-source product.
In my opinion, Storm is much easier to learn than SQLAlchemy. Is similar to Django's ORM.