DOM API inconsitencies aside (which is what libraries solve), there aren't many.
But some JS engines have implemented more features, like [].map(), [].filter() etc, let statement or E4X. When I switch between Mozilla-targeted development (Firefox extensions, server-side with Jaxer) and general browser tageted development (websites) I need to remember what's available in every browser, and what isn't. So it's all about what is implemented, not how it is done.