When debugging in chrome, the scripts are always paused in the debugger even if there are no break points set, and if the the pause is un-paused, it again pauses itself.
Click on the Settings icon and then click on the Restore defaults and reload button. This worked for me whereas the accepted answer didn't.
This can also cause the issue
Break Point icon at top right should be blue like this
Should not grey like this
One possible cause, it that you've enabled the "pause on exceptions" (the little stop-sign shaped icon with the pause (||) symbol with in in the lower left of the window). Try clicking that back to the off/grey state (not red nor blue states) and reload the page.
UPDATE: Adding a screenshot for reference:
Another user mentioned this in slight detail but I missed it until I came back here about 3 times over 2 days -
There is a section titled EventListener breakpoints that contains a list of other breakpoints that can be set. It happens that I accidentally enabled one of them on DOM Mutation that was letting me know whenever anything to the DOM was overridden. Unfortunately this led to me disabling a bunch of plug-ins and add-ons before I realized it was just my machine. Hope this helps someone else.
Threads > switch "Main" to "app"
In the "Threads" section I changed the context from "Main" > to "app". The "app" should have a blue arrow aside.
And there is some options below ,if you have checked some,when the condition is active,the breakpoint debugger also active