Good day, sorry for the seemingly broad question title.
I am building an ExtJS4 application using php and sql for the user data. Everything was going fine until one
I had this error a while a ago. It is caused by Ext.Loader which loads the Ext classes dynamically.
I could solve it by adding the required classes in the Ext.require([...]) statement in the main js file of my application (i.e. app.js).
The docs for Ext.Loader explain when and why asynchronous and synchronous loading happens.
Not sure about the main question, never seen that before with extjs 4 apps I have written.
For the question in loading the application faster you should be using sencha CMD to produce a concatenated and minified version of your source for using in a production environment.
Edit
I just came across this SO - "Synchronous XMLHttpRequest on the main thread is deprecated" using nodejs app.get or http-server
Talks about the same issue but with a different framework and comments suggests its an error on client side. Have you changed much lately with how your are fetching data from the server?