I have the following in my web.config
Even if it's a bad idea to modify the web.config
file from inside an app, you can try this:
System.Configuration.ConfigurationManager.AppSettings.Set("keyToBeReplaced", "newKeyValue");
Basically, you need to forget about the web.config, and structure your code to use a connection string the exist only in memory.
If a user is able to change the value of the Setting, then the web.config file is the wrong place to store the setting.
You should check out a User Scoped value in a Settings file instead.
MSDN - Using Settings in C#
When using settings like this, changing the value at runtime is easy:
Properties.Settings.Default.LdapConnectionString = "New Connection String";
Properties.Settings.Default.Save();
var settings = ConfigurationManager.ConnectionStrings[ 0 ];
var fi = typeof( ConfigurationElement ).GetField( "_bReadOnly", BindingFlags.Instance | BindingFlags.NonPublic );
fi.SetValue(settings, false);
settings.ConnectionString = "Data Source=Something";