I have saved some screenshots in the iPhone Simulator running iOS 5, but I can\'t find them.
I had this problem before, and it took me frickin\' ages to find them i
Change the device: Hardware>Device>iPhone(Retina 4-inch)
Press Command + S
Screenshot will automatically come on your desktop
I found it here
Library/Developer/CoreSimulator/Devices/(UDID)/data/Media/DCIM
By default, screenshots are saved on the desktop.
Press command + S. take sreen shot and it will store in Desktop See Example
They get saved to the Desktop, look for a PNG file with the naming convention "iOS Simulator Screen shot [DATE].png"
I had exactly the same problem but I found that although (Command+s) didn't save the image to the desktop (Command+Ctrl+C) did copy the screenshot to the clipboard. You can then open and save the screenshot using Preview.