1) First you need to enable Proguard even without obfuscation. It will remove unused Java code from your dependencies.
2) Second, use 9-patch images instead of very high resolution images.
3) Remove some unnecessary code and also JAR files that haven't be used.
4) Ensure you are using .png images instead of .jpg.
5) Use different images for different screen resolutions.
6) Check your layout folder for unnecessary XML files