If you can come up with a way of comparing images that obeys the triangle inequality (eg, if d(a,b) is the difference between images a and b, then d(a,b) < d(a,c) + d(b,c) for all a,b,c), then a BK-Tree would be an effective way of indexing the images such that you can find matches in O(log n) time instead of O(n) time for each image.
If your matches are restricted to the same image after varying amounts of compression/resizing/etc, then converting to some canonical size/color balance/etc and simply summing the squares-of-differences of each pixel may be a good metric, and this obeys the triangle inequality, so you could use a BK-tree for efficient access.