I have used them for sending larger amounts of data from the browser to server. Obviously, you can do this with regular AJAX calls, but if this takes up one of the precious connections per hostname. Also, if the user does a page transition during this process (e.g clicks a link), your JavaScript objects from the previous page go away and you can't process callbacks. When a web worker is used, this activity happens out of band, so you have a better guarantee that it will complete.