A client wants to \"Web-enable\" a spreadsheet calculation -- the user to specify the values of certain cells, then show them the resulting values in other cells.
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Neglecting the discussion whether it makes sense to manipulate an excel sheet on the server-side, one way to perform this would probably look like adopting the
Microsoft.Office.Interop.Excel.dll
Using this library, you can tell Excel to open a Spreadsheet, change and read the contents from .NET. I have used the library in a WinForm application, and I guess that it can also be used from ASP.NET.
Still, consider the concurrency problems already mentioned... However, if the sheet is accessed unfrequently, why not...