The fact that the sort values in the OP are integers isn't relevant to the question per se. In other words, the accepted answer would work if the sort value was text. I bring this up to also point out that the sort can be modified during the sort (for example, to account for upper and lower case).
>>> sorted([(121, 'abc'), (231, 'def'), (148, 'ABC'), (221, 'DEF')], key=lambda x: x[1])
[(148, 'ABC'), (221, 'DEF'), (121, 'abc'), (231, 'def')]
>>> sorted([(121, 'abc'), (231, 'def'), (148, 'ABC'), (221, 'DEF')], key=lambda x: str.lower(x[1]))
[(121, 'abc'), (148, 'ABC'), (231, 'def'), (221, 'DEF')]