Get and store text, set text temporarily to one line of value (like "x" or " "), get and store .height (or .inner, or .outer, whatever you need), replace text with stored value. Show if necessary (eg, the element is hidden), then hide again if necessary.
This (.height) will give you the total line height (font size plus line height adjustment) in a numeral (like 15 for font size 12 and line height 1.25).
Use a hidden div to do all this if necessary, show, get height, hide.
This alert shows the numeral value 15, all browsers:
<div id="TestDiv">
Any text you want.
</div>
jQuery(document).ready(function()
{
var TestText = $("#TestDiv").text();
var TestDivLineHeight = $("#TestDiv")
.css("font-size", "12px").css("line-height", "1.25").text("x").height();
alert(TestDivLineHeight);
$("#TestDiv").text(TestText);
});