So, my answer to a previous similar question is to learn Objective-C. (Also, don't forget about debugging support)
This will probably offend some but to
be honest, if you are going to do any
serious development, you should learn
Objective-C. Not knowing Objective-C
in iPhone development will just be a
hindrance. You won't be able to
understand many examples; you have to
deal with the quirks of Mono whereas
if you had a working knowledge of
Objective-C you could get a lot more
out of the platform documentation.
Personally, I don't understand the
position that says increasing the
amount of information you need in
favor of using Mono over the
platform's native language. It seems
somewhat counterproductive to me. I
think if this is a very expensive
proposition (learning a new language)
then it may be worthwhile spending
some time on fundamental programming
concepts so that learning new
languages is a fairly cheap
proposition.
Another user also wrote this:
Monotouch is easier for you now. But harder later.
For example, what happens when new seeds come out you need to test against but break MonoTouch for some reason?
By sticking with Mono, any time you are looking up resources for frameworks you have to translate mentally into how you are going to use them with Mono. Your app binaries will be larger, your development time not that much faster after a few months into Objective-C, and other app developers will have that much more of an advantage over you because they are using the native platform.
Another consideration is that you are looking to use C# because you are more familiar with the language than Objective-C. But the vast majority of the learning curve for the iPhone is not Objective-C, it is the frameworks - which you will have to call into with C# as well.
For any platform, you should use the platform that directly expresses the design philosophy of that platform - on the iPhone, that is Objective-C. Think about this from the reverse angle, if a Linux developer used to programming in GTK wanted to write Windows apps would you seriously recommend that they not use C# and stick to GTK because it was "easier" for them to do so?