There are all sorts of things you can look out for, but it doesn't really give you any certainty as to the technology behind a site. In general, information like that is something people will want to hide, as the more information that is exposed the easier it might be for malicious parties to identify security vulnerabilities or denial of service holes.
If I was interested I'd probably look, in no particular order, at:
- urls, and file extensions.
- HTTP response headers
- Source code for comments, or standard JS libraries
Incidentally, the tools mentioned in other answers are only looking at some of the above properties of the site for you, albeit automatically, and slightly quicker. :)