When trying to execute from within Visual Studio 2008 your application and you get the (uninformative) message \"The operation could not be completed\".
The solution
Is your project output folder set to a network share?
If so, try changing it to a local folder and see what happens. It appears that VS is not always able to terminate the process if the host exe is running from a share.
The other possibility is that the project is open and running in debug mode on another instance of Visual Studio - although I suspect you will allready have ensured this is not the case.