I\'m trying to solve a Rosalind basic problem of counting nucleotides in a given sequence, and returning the results in a list. For those ones not familiar with bioinformati
As others have already noted, you are comparing fairly specific code against fairly general one.
Consider that something as trivial as spelling out the loop over the characters you are interested in is already buying you a factor 2, i.e.
def char_counter(text, chars='ACGT'):
return [text.count(char) for char in chars]
%timeit method1(short_seq)
# 100000 loops, best of 3: 18.8 µs per loop
%timeit char_counter(short_seq)
# 10000 loops, best of 3: 40.8 µs per loop
%timeit method1(long_seq)
# 10 loops, best of 3: 172 ms per loop
%timeit char_counter(long_seq)
# 1 loop, best of 3: 374 ms per loop
Your method1()
is the fastest but not the most efficient, as the input is looped through entirely for each char you are inspecting, thereby not taking advantage of the fact that you could easily short-circuit your looping as soon as a character gets assigned to one of the character classes.
Unfortunately, Python does not offer a fast method to take advantage of the specific conditions of your problem.
However, you could use Cython for this, and you would then be able to outperform your method1()
:
%%cython -c-O3 -c-march=native -a
#cython: language_level=3, boundscheck=False, wraparound=False, initializedcheck=False, cdivision=True, infer_types=True
import numpy as np
cdef void _count_acgt(
const unsigned char[::1] text,
unsigned long len_text,
unsigned long[::1] counts):
for i in range(len_text):
if text[i] == b'A':
counts[0] += 1
elif text[i] == b'C':
counts[1] += 1
elif text[i] == b'G':
counts[2] += 1
else:
counts[3] += 1
cpdef ascii_count_acgt(text):
counts = np.zeros(4, dtype=np.uint64)
bin_text = text.encode()
return _count_acgt(bin_text, len(bin_text), counts)
%timeit ascii_count_acgt(short_seq)
# 100000 loops, best of 3: 12.6 µs per loop
%timeit ascii_count_acgt(long_seq)
# 10 loops, best of 3: 140 ms per loop
The time difference here is pretty simple to explain. It all comes down to what runs within Python and what runs as native code. The latter will always be faster since it does not come with lots of evaluation overhead.
Now that’s already the reason why calling str.count()
four times is faster than anything else. Although this iterates the string four times, these loops run in native code. str.count
is implemented in C, so this has very little overhead, making this very fast. It’s really difficult to beat this, especially when the task is that simple (looking only for simple character equality).
Your second method, of collecting the counts in an array is actually a less performant version of the following:
def method4 (seq):
a, c, g, t = 0, 0, 0, 0
for i in seq:
if i == 'A':
a += 1
elif i == 'C':
c += 1
elif i == 'G':
g += 1
else:
t += 1
return [a, c, g, t]
Here, all four values are individual variables, so updating them is very fast. This is actually a bit faster than mutating list items.
The overall performance “problem” here is however that this iterates the string within Python. So this creates a string iterator and then produces every character individually as an actual string object. That’s a lot overhead and the main reason why every solution that works by iterating the string in Python will be slower.
The same problem is with collection.Counter
. It’s implemented in Python so even though it’s very efficient and flexible, it suffers from the same issue that it’s just never near native in terms of speed.
It's not because collections.Counter
is slow, it's actually quite fast, but it's a general purpose tool, counting characters is just one of many applications.
On the other hand str.count
just counts characters in strings and it's heavily optimized for its one and only task.
That means that str.count
can work on the underlying C-char
array while it can avoid creating new (or looking up existing) length-1-python-strings during the iteration (which is what for
and Counter
do).
Just to add some more context to this statement.
A string is stored as C array wrapped as python object. The str.count
knows that the string is a contiguous array and thus converts the character you want to co to a C-"character", then iterates over the array in native C code and checks for equality and finally wraps and returns the number of found occurrences.
On the other hand for
and Counter
use the python-iteration-protocol. Each character of your string will be wrapped as python-object and then it (hashes and) compares them within python.
So the slowdown is because:
Counter
in python 3.x because it was rewritten in C)Note the reason for the slowdown is similar to the question about Why are Python's arrays slow?.
I did some additional benchmarks to find out at which point collections.Counter
is to be preferred over str.count
. To this end I created random strings containing differing numbers of unique characters and plotted the performance:
from collections import Counter
import random
import string
characters = string.printable # 100 different printable characters
results_counter = []
results_count = []
nchars = []
for i in range(1, 110, 10):
chars = characters[:i]
string = ''.join(random.choice(chars) for _ in range(10000))
res1 = %timeit -o Counter(string)
res2 = %timeit -o {char: string.count(char) for char in chars}
nchars.append(len(chars))
results_counter.append(res1)
results_count.append(res2)
and the result was plotted using matplotlib:
import matplotlib.pyplot as plt
plt.figure()
plt.plot(nchars, [i.best * 1000 for i in results_counter], label="Counter", c='black')
plt.plot(nchars, [i.best * 1000 for i in results_count], label="str.count", c='red')
plt.xlabel('number of different characters')
plt.ylabel('time to count the chars in a string of length 10000 [ms]')
plt.legend()
The results for Python 3.6 are very similar so I didn't list them explicitly.
So if you want to count 80 different characters Counter
becomes faster/comparable because it traverses the string only once and not multiple times like str.count
. This will be weakly dependent on the length of the string (but testing showed only a very weak difference +/-2%).
In Python-2.7 collections.Counter
was implemented using python (instead of C) and is much slower. The break-even point for str.count
and Counter
can only be estimated by extrapolation because even with 100 different characters the str.count
is still 6 times faster.