Disclaimer: I work for a company, Particle Code, that makes a cross-platform framework. There are a ton of companies in this space. New ones seem to spring up every week. Good news for you: you have a lot of choices.
These frameworks take different approaches, and many of them are fundamentally designed to solve different problems. Some are focused on games, some are focused on apps. I would ask the following questions:
What do you want to write? Enterprise application, personal productivity application, puzzle game, first-person shooter?
What kind of development environment do you prefer? IDE or plain ol' text editor?
Do you have strong feelings about programming languages? Of the frameworks I'm familiar with, you can choose from ActionScript, C++, C#, Java, Lua, and Ruby.
My company is more in the game space, so I haven't played as much with the JavaScript+CSS frameworks like Titanium, PhoneGap, and Sencha. But I can tell you a bit about some of the games-oriented frameworks. Games and rich internet applications are an area where cross-platform frameworks can shine, because these applications tend to place more importance of being visually unique and less on blending in with native UIs. Here are a few frameworks to look for:
Unity www.unity3d.com is a 3D games engine. It's really unlike any other development environment I've worked in. You build scenes with 3D models, and define behavior by attaching scripts to objects. You can script in JavaScript, C#, or Boo. If you want to write a 3D physics-based game that will run on iOS, Android, Windows, OS X, or consoles, this is probably the tool for you. You can also write 2D games using 3D assets--a fine example of this is indie game Max and the Magic Marker, a 2D physics-based side-scroller written in Unity. If you don't know it, I recommend checking it out (especially if there are any kids in your household). Max is available for PC, Wii, iOS and Windows Phone 7 (although the latter version is a port, since Unity doesn't support WinPhone). Unity comes with some sample games complete with 3D assets and textures, which really helps getting up to speed with what can be a pretty complicated environment.
Corona www.anscamobile.com/corona is a 2D games engine that uses the Lua scripting language and supports iOS and Android. The selling point of Corona is the ability to write physics-based games very quickly in few lines of code, and the large number of Corona-based games in the iOS app store is a testament to its success. The environment is very lean, which will appeal to some people. It comes with a simulator and debugger. You add your text editor of choice, and you have a development environment. The base SDK doesn't include any UI components, like buttons or list boxes, but a CoronaUI add-on is available to subscribers.
The Particle SDK www.particlecode.com is a slightly more general cross-platform solution with a background in games. You can write in either Java or ActionScript, using a MVC application model. It includes an Eclipse-based IDE with a WYSIWYG UI editor. We currently support building for Android, iOS, webOS, and Windows Phone 7 devices. You can also output Flash or HTML5 for the web. The framework was originally developed for online multiplayer social games, such as poker and backgammon, and it suits 2D games and apps with complex logic. The framework supports 2D graphics and includes a 2D physics engine.
NB:
Today we announced that Particle Code has been acquired by Appcelerator, makers of the Titanium cross-platform framework.
...
As of January 1, 2012, [Particle Code] will no longer officially support the [Particle SDK] platform.
Source
- The Airplay SDK www.madewithmarmalade.com is a C++ framework that lets you develop in either Visual Studio or Xcode. It supports both 2D and 3D graphics. Airplay targets iOS, Android, Bada, Symbian, webOS, and Windows Mobile 6. They also have an add-on to build AirPlay apps for PSP. My C++ being very rusty, I haven't played with it much, but it looks cool.
In terms of learning curve, I'd say that Unity had the steepest learning curve (for me), Corona was the simplest, and Particle and Airplay are somewhere in between.
Another interesting point is how the frameworks handle different form factors. Corona supports dynamic scaling, which will be familiar to Flash developers. This is very easy to use but means that you end up wasting screen space when going from a 4:3 screen like the iPhone to a 16:9 like the new qHD Android devices. The Particle SDK's UI editor lets you design flexible layouts that scale, but also lets you adjust the layouts for individual screen sizes. This takes a little more time but lets you make the app look custom made for each screen.
Of course, what works for you depends on your individual taste and work style as well as your goals -- so I recommend downloading a couple of these tools and giving them a shot. All of these tools are free to try.
Also, if I could just put in a public service announcement -- most of these tools are in really active development. If you find a framework you like, by all means send feedback and let them know what you like, what you don't like, and features you'd like to see. You have a real opportunity to influence what goes into the next versions of these tools.
Hope this helps.