You can use the Closure compiler to compile your javascript.
You can also use CoffeeScript to compile your coffeescript to javascript.
What do you want to achieve with compiling?
The task of compiling arbitrary non-blocking JavaScript down to say, C sounds very daunting.
There really isn't that much speed to be gained by compiling to C or ASM. If you want speed gain offload computation to a C program through a sub process.