NW.js
(Previously known as node-webkit)
I would suggest NW.js if you are familiar with Node or experienced with JavaScript.
NW.js is an app runtime based on Chromium and node.js.
Features
- Apps written in modern HTML5, CSS3, JS and WebGL
- Complete support for Node.js APIs and all its third party modules.
- Good performance: Node and WebKit run in the same thread: Function calls are made straightforward; objects are in the same heap and can just reference each other
- Easy to package and distribute apps
- Available on Linux, Mac OS X and Windows
You can find the NW.js repo here, and a good introduction to NW.js here. If you fancy learning Node.js I would recommend this SO post with a lot of good links.