I recently upgraded to Snow Leopard and since then I am having difficulty running Instrument to instrument my app from Xcode. The Record button would be grayed out, and nothing
Make sure all of your instruments support recording modes. When I upgraded from Xcode6 to Xcode7, one of my instruments was marked as "This instrument's supported recording modes are none". When I deleted this specific instrument, the recording button becomed enabled.
I had this issue in Xcode 7. It turned out that, somehow, in the Profile section of my scheme settings, the Executable field had been cleared:
I set the Executable field to my target name and the menu enabled again.
Note that if you have multiple targets, it is very likely that you need indeed to tell Xcode which one you want to profile. Use the edit targets scheme above