I cannot find any example on the net of how the SQLite 3 vacuum command is done on a database.
Just open a connection and execute the VACUUM command;
conn=sqlite3.connect(SQLITE_FILE)
conn.execute("VACUUM")
conn.close()
import sqlite3
con = sqlite3.connect(<file_name>)
..
con.execute("VACUUM")
..
the other solutions didn't work for me Error was "can't vacuum with transaction" or similar
here what worked for me:
import sqlite3
conn = sqlite3.connect('my_test.db', isolation_level=None)
conn.execute("VACUUM")
conn.close()